June 18, 2013

Zhou et al, Environmental Fluoride Exposure and Reproductive Hormones in Males Living in Endemic Fluorosis Villages in China

ABSTRACT

Objective. To explore the influence of high fluoride exposure on reproductive hormones in male living in endemic fluorosis villages in China.

Methods. A cross sectional study was conducted in Tongxu county in Henan Province, China. Endemic fluorosis villages and control villages were selected by random sampling according to fluoride concentration in drinking water and the prevalence of endemic fluorosis. Local male residents aged from 18 to 50 years old who were born and grew up in the investigated villages were recruited as subjects by cluster sampling. Fasting blood and urine samples were collected. The serum level of GnRH was detected using ELISA. The serum level of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), and testosterone (T) were determined by chemiluminesence immunoassay (CLIA).

Results. The serum levels of FSH were 7.82 mlU/ml, 10.20 mIU/ml and 9.57 mIU/ml in male from defluoridation villages (DFPG), high fluoride villages (HFG) and control villages (CG) respectively. FSH level in male from DFPG was significant lower than that from HFG and CG (P<0.05). The serum levels of E2 were 33.67 ng/mL, 29.17 ng/mL and 28.99 ng/mL in DPFG, HFG and CG respectively. E2 level in male from DFPG was significant higher than that from HFG and CG (P<0.05). Serum levels of E2 in CG were associated with LH (r=0.343, P=0.000), age (r=0.195, P=0.015), and inversely associated with serum FSH (r=-0.237, P=0.003), whereas this correlation was not observed for serum E2 level in DFPG and HFG.

Conclusion. Long-term fluoride exposure in drinking water may influence the reproductive hormones in males living in endemic fluorosis villages.

Zhou et al, Environmental Fluoride Exposure And Reproductive Hormones In Males Living In Endemic Fluorosis Villages In China, Life Science Journal, Jul-2012

Impact of Fluoride on Neurological Development in Children

By: Marge Dwyer, Harvard School of Public Health News, Boston, MA July 2012 — For years health experts have been unable to agree on whether fluoride in the drinking water may be toxic to the developing human brain. Extremely high levels of fluoride are known to cause neurotoxicity in adults, and negative impacts on memory and learning have been reported in rodent studies, but little is known about the substance’s impact on children’s neurodevelopment. In a meta-analysis, researchers from Harvard School of Public Health (HSPH) and China Medical University in Shenyang for the first time combined 27 studies and found strong indications that fluoride may adversely affect cognitive development in children. Based on the findings, the authors say that this risk should not be ignored, and that more research on fluoride’s impact on the developing brain is warranted.

The study was published online in Environmental Health Perspectives on July 20, 2012.

The researchers conducted a systematic review of studies, almost all of which are from China where risks from fluoride are well-established. Fluoride is a naturally occurring substance in groundwater, and exposures to the chemical are increased in some parts of China. Virtually no human studies in this field have been conducted in the U.S., said lead author Anna Choi, research scientist in the Department of Environmental Health at HSPH.

Even though many of the studies on children in China differed in many ways or were incomplete, the authors consider the data compilation and joint analysis an important first step in evaluating the potential risk. “For the first time we have been able to do a comprehensive meta-analysis that has the potential for helping us plan better studies. We want to make sure that cognitive development is considered as a possible target for fluoride toxicity,” Choi said.

Choi and senior author Philippe Grandjean, adjunct professor of environmental health at HSPH, and their colleagues collated the epidemiological studies of children exposed to fluoride from drinking water. The China National Knowledge Infrastructure database also was included to locate studies published in Chinese journals. They then analyzed possible associations with IQ measures in more than 8,000 children of school age; all but one study suggested that high fluoride content in water may negatively affect cognitive development.

The average loss was only half of one IQ point, but some studies suggested that even slightly increased fluoride exposure could be toxic to the brain. Thus, children in high-fluoride areas had significantly lower IQ scores than those who lived in low-fluoride areas. The children studied were up to 14 years of age, but the investigators speculate that any toxic effect on brain development may have happened earlier, and that the brain may not be fully capable of compensating for the toxicity.

“Fluoride seems to fit in with lead, mercury, and other poisons that cause chemical brain drain,” Grandjean says. “The effect of each toxicant may seem small, but the combined damage on a population scale can be serious, especially because the brain power of the next generation is crucial to all of us.”

http://cof-cof.ca/wp-content/uploads/2012/09/Impact-of-Fluoride-on-Neurological-Development-in-Children-July-25-2012-Features-News-at-HSPH-Harvard-School-of-Public-Health.pdf

http://www.hsph.harvard.edu/news/features/features/fluoride-childrens-health-grandjean-choi.html

http://cof-cof.ca/2012/07/choi-et-al-developmental-fluoride-neurotoxicity-a-systematic-review-and-meta-analysis-environmental-health-perspectives-20-jul-2012/

Choi et al, Developmental Fluoride Neurotoxicity – A Systematic Review and Meta-Analysis

ABSTRACT

Background: Although fluoride may cause neurotoxicity in animal models and acute fluoride poisoning causes neurotoxicity in adults, very little is known of its effects on children’s neurodevelopment.

Objective: We performed a systematic review and meta-analysis of published studies to investigate the effects of increased fluoride exposure and delayed neurobehavioral development.

Methods: We searched the MEDLINE, EMBASE, Water Resources Abstracts, and TOXNET databases through 2011 for eligible studies. We also searched the China National Knowledge Infrastructure (CNKI) database, as many studies on fluoride neurotoxicity have been published in Chinese journals only. In total, we identified 27 eligible epidemiological studies with high and reference exposures, endpoints of IQ scores or related cognitive function measures with means and variances for the two exposure groups. We estimated the standardized mean difference (SMD) between exposed and reference groups across all studies using random effects models. We conducted sensitivity analyses restricted to studies using the same outcome assessment and having drinking water fluoride as the only exposure. Cochran test for heterogeneity between studies, Begg’s funnel plot and Egger test to assess publication bias were performed. Metaregressions to explore sources of variation in mean differences among the studies were conducted.

Results: The standardized weighted mean difference in IQ score between exposed and reference populations was -0.45 (95% CI -0.56 to -0.35) using a random-effects model. Thus, children in high fluoride areas had significantly lower IQ scores than those who lived in low fluoride areas. Subgroup and sensitivity analyses also indicated inverse associations, although the substantial heterogeneity did not appear to decrease.

Conclusions: The results support the possibility of an adverse effect of high fluoride exposure on children’s neurodevelopment. Future research should include detailed individual-level information on prenatal exposure, neurobehavioral performance, and covariates for adjustment.

Choi et al, Developmental Fluoride Neurotoxicity – A Systematic Review and Meta-Analysis, Environmental Health Perspectives 20-Jul-2012

Supplemental Material – Choi et al, Developmental Fluoride Neurotoxicity – A Systematic Review and Meta-Analysis, Environmental Health Perspectives 20-Jul-2012

Health Canada indicates one tablespoon of fluoridated water per day for baby is enough

1 litre (L) of water = 1000 millilitres (mL) of water

1 tablespoon of water = 15 millilitres (mL) of water

15 millilitres (mL) of water =  0.015 L of water (15 ÷1000)

artificially fluoridated water typically contains about 0.7 milligrams (mg) of fluoride per litre … that’s 0.7 mg/L

1 tablespoon of 0.7 mg/L fluoridated water contains 0.0105 mg fluoride (0.7 mg x 0.015 L)

Health Canada claims “adequate intake” of daily fluoride for babies is 0.01 mg of fluoride (10 micrograms).

 That’s one tablespoon of fluoridated water
p
er day for baby !

Orillia – Higher quality water & better at flighting cavities by remaining fluoridation free

By: Staff Writer, Canadians Opposed to Fluoridation ~ Canadiens Opposés à la Fluoration, Orillia, Ontario 17-Jul-2012 — The individuals pushing a fluoridation agenda onto Orillia were desperate for a new fluoridation scheme to begin somewhere (anywhere) in Ontario.  After all, there hasn’t been one since the mid 1990′s.

Orillia was chosen, not due to its dental decay rates, but because it was assumed the Medical Officer of Health and the Dental-Medical community could be manipulated into supporting an outdated unproven practice.

Fortunately, 7 out of 9 Orillia council members weren’t blinded by such smoke and mirrors.  They saw the manipulation of white coat authorities, and didn’t buy into leverage about socioeconomically challenged citizens needing fluoridation as a means of reducing dental decay rates.

Under the guise of ‘helping the poor wee children’, Health Canada’s chief dental officer swooped in to spin a tale of dread and woe.  Yet, Health Canada never accepts liability for the chronic harms that water fluoridation is known to cause, including dental fluorosis (a discolouration, mottling, weakening of dental enamel proportionate to the amount of fluoride you swallow).

One must ask why, when a state of the art water plant was built in Barrie, no fluoridation equipment was included?  Particularly, when Barrie’s natural source water fluoride concentration is 2.8 to 4 times lower than Orillia’s, as evidenced in the Barrie and Orillia drinking water quality reports.  One must also ask, how can dental decay rates be lower in Barrie, when it has less fluoride in the water than Orillia?  Obviously, lack of fluoridation doesn’t result in higher decay rates, so adding fluoride into Orillia’s drinking water won’t reduce decay rates.

What will reduce decay rates is proper tooth brushing, flossing and frequent rinsing.  Keeping away from processed foods, as well as foods and drinks made with refined sugars.  Eating naturally healthy nutritious foods.  Rejecting smoking.  Ensuring sufficient uptake of calcium and vitamin D3.  These are all lifestyle changes that individuals have free choice and control over, which genuinely do improve oral health.  It’s the individual’s responsibility, and the responsibility of parents for their children.  It’s common sense that can’t be legislated, but it can be taught and mentored.  Partner with, and contribute to, the programs which can deliver such opportunities for those who cannot achieve them on their own.

Well done Orillia City Council and staff!  Your drinking water remains higher quality and safer when it’s fluoridation free.

http://cof-cof.ca/2012/07/6717/

City of Orillia says NO to water fluoridation

By: Sara Ross, Orillia Packet & Times, Orillia, Ontario 16-Jul-2012 — Orillia’s politicians have said no to fluoridating the municipal water supply.

“I just believe there has to be alternatives,” Mayor Angelo Orsi said at Monday’s council committee meeting. “This is a very touchy decision when you’re basically dealing with freedom of choice.”

The Simcoe Muskoka District Health Unit (SMDHU) and city staff recommended Orillia fluoridate the water supply. Statistics show Orillia children have the highest rate of dental decay of the 10 municipalities reviewed in the Simcoe-Muskoka region.

Councillors Linda Murray and Tony Madden were the only ones to vote in favour of fluoridation.

“The mayor said he would like to see alternative methods,” Murray said. “You’re fortunate enough to be able to take your children to the dentist. I can’t tell you how many do not have that ability.”

Council committee received a report from city staff regarding fluoridating the water supply as information, but voted 7-2 against fluoridating the water.

The decision was ratified by council later in the evening.

Coun. Andrew Hill suggested the city recommend Orillians drink more water.

“It really takes away the freedom of choice,” he said. “The majority of people I’ve talked to in my ward do not want it.”

There is naturally occurring fluoride in Orillia’s water supply of roughly .2 milligrams per litre. The optimal concentration is between .5 and .8 milligrams per litre, according to the Ministry of the Environment.

“We don’t have at our disposal recommendations on the effectiveness of merely advising people to drink larger quantities of water to try and get that degree of exposure,” said Charles Gardner, medical officer of health and CEO of the SMDHU. “…Therefore, we wouldn’t be in a position to advise that that would be a good alternative.”

Hill said he’s read hundreds of pages on the pros and cons of fluoridation.

“There’s so many different educated people on both sides of the argument,” he said. “To myself and to my constituents, I would err on the side of caution and I will be voting against it.”

Orsi would like to see the SMDHU bring more awareness and education to schools. He suggested alternatives would be drinking water and properly brushing teeth.

“I understand and believe fluoride works on your teeth and works very well,” he said.

Oral hygiene, food nutrition and regular preventative dental care all contribute to the prevention of cavities, Gardner said.

“In addition to all of those things, fluoridation of community water supply further protects teeth,” he said. “We would advise all of those things be in place.”

Gardner added schools are directed to inform youth on oral hygiene.

Adding fluoride to the water supply would have a “major” positive impact on the city, Madden said.

“It’s not necessarily the people around this (council) table and the people in the audience who naturally take good care of their teeth,” he said. “There’s a lot of people in our city who just don’t, and don’t have the same socioeconomic opportunities as others.”

Madden suggested if Orillians have better teeth, they’ll have more confidence.

“They’ll be more outwardly confident to seek better education, better jobs and bring up the overall socioeconomic status of our city,” he said.

He noted Orillia doctors and dentists were recommending fluoride be added.

“I personally put a lot of weight and value in that advice,” he said.

Murray does as well.

“If your doctor gives you medical advice, 9.9 times out of 10 we’re going to accept it,” she said. “We’re not going to say, ‘I’m smarter than you. I have more information than you.’”

She noted milk has vitamin D added to it, salt has iodine and water has chlorine.

From October 2011 to May of this year, Orillia had two public forums and six community group presentations regarding fluoride. Also, Orillia Citizens Against Fluoridation made a deputation to council in May.

Residents seem to be “divided,” staff stated in a report.

“Approximately 85% of individuals submitting input during the public consultation process have been opposed,” staff said.

However, independent polling conducted as recently as 2011 indicated 64% of randomly selected Orillians supported adding fluoride to public drinking water, with 25% opposed and 11% undecided, the report states.

“The people that we’re hearing from are not the silent majority that support fluoridation, but those who are actively going from community to community against fluoridation,” Murray said. “A decision not to fluoridate would be a regrettable, missed opportunity to improve community health and (would be) a major disservice to our residents.”

If fluoridation had been approved, renovations would have been needed at the west Orillia well and water treatment plant in order to store the fluoride at an estimated cost of $160,000 to $180,000.

“Not only is fluoridation affordable; it will actually save money,” Murray said. “Thirty-eight dollars in direct dental cost for every $1 spent.”

http://www.orilliapacket.com/2012/07/16/city-says-no-to-fluoride

Rosetown, Saskatchewan stops artificially fluoridating the town’s drinking water

By: COF-COF, Rosetown, Saskatchewan, 16-July-2012 – Rosetown has made a change to the town’s water supply.

The community of approximately 2300 people will no longer receive artificially fluoridated water.

After the town’s fluoridation feed-pump broke down, a decision was made that there is already a sufficient amount of fluoride in the town’s well water.

Background levels of natural fluoride throughout the town wells is said to be at approximately 0.5 ppm (mg/L). The town considers this to be an acceptable amount, therefore, there is no need to repair the broken pump.

Most recently, Health Canada suggested municipalities adopt a level of 0.7 ppm (mg/L) as the ‘optimal’ target concentration for fluoride in
drinking water.

Town council meetings are held on the 3rd Monday of every month.

Global News, Calgary, Alberta – One Year After Fluoridation Was Turned Off

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Global News, Calgary, Alberta (11-Jul-2012, 1 min. 54 sec.)

City council voted to remove fluoride from Calgary’s drinking water on February 8, 2011.  Hydrofluorosilicic acid fluoridation was shut off on May 19, 2011.  According to water department staff it took approximately two more weeks for artificial fluoride to clear the city’s distribution system.  It’s now just over a year since fluoridation has been off, so are dentists really seeing a difference in local young patient’s cavity rates?  Listen closely for the real root cause of this dental decay — sugar and sugary children’s drinks — and how best to address this problem.

Comprehensive Preventitive Dentistry, Edited By Dr. Hardy Limeback DDS

Comprehensive Preventitive Dentistry, 2012
Edited By: Dr. Hardy Limeback DDS

Comprehensive Preventive Dentistry provides one user-friendly resource that brings together information on the scientific basis and clinical practice of all aspects of preventive dentistry. This thorough and all-encompassing resource offers techniques and strategies for maintaining excellent oral health in patients through a regimen of preventive measures.

Comprehensive Preventive Dentistryis grounded in a patient-centered, pre-emptive, and minimally invasive philosophy. The book begins by covering individual diseases, such as caries, periodontitis, and oral cancer, as well as therapies (sealants, fluoride) and other relevant conditions (toothwear, hypersensitivity). Additionally, concepts such as the role of diet and nutrition in oral health are discussed. Also covered are oral care products and new techological developments in caries diagnosis and risk assessment, periodontal disease and oral cancer, as well as new developments in home care products.

A valuable and comprehensive companion that will appeal to dentists and dental hygienists, this helpful new book provides its readers with one authoritative resource that offers a reliable and helpful companion to practicing preventive dentistry.

purchase book on-line

Notice: Canadians Opposed to Fluoridation ~ Canadiens Opposés à la Fluoration (COF-COF) receives no money or incentives whatsoever for any book recommendations or any book purchases.

Calgary earmarks $750,000 from flouridation savings for kids’ dental care programs

By: Sherri Zickefoose, Calgary Herald, Calgary, Ontario 04-Jul-2012 — The city is closer to washing its hands of dental-care delivery by  recommending one-time funding for charities.

The city has earmarked $750,000 saved from shutting off fluoride injection  into city drinking water last year to go toward alternative anti-cavity programs  for children living in poverty.

On Wednesday, council’s community and protective services committee approved  a plan to divvy one-time capital funding among the Alex and Calgary Urban  Project Society because they already have health services in place.

“We stopped doing something that perhaps wasn’t our responsibility but we’d  been doing it for decades,” said Ald. Druh Farrell, who led the initial charge  to stop medicating Calgarians through drinking water.

“So this is to provide a transition and we’ve made a very clear statement  that we’re not in the business of providing health care,” she said.

“I recognize this is provincial responsibility to provide health care. We did  make a commitment to take some of the savings and put it into whole dental  health for children of low income.”

“It is short-term, it is capital and I think that’s an important principle.  They’re sound recommendations that help a lot of kids who need our help,” she  said.

Ald. Jim Stevenson said he supports the charities involved, but opposes the  funding plan, which council will debate later.

“My problem is that once again, we’re moving into funding what the Alberta  government should be funding. It’s very difficult for me to support taking  three-quarters of a million dollars and putting it into funding that’s not our  responsibility when there are so many requests that are our responsibility that  we can’t fill.”

The city is not prepared to continue funding the projects, but rather offer  capital.

“It’s not something that’s going to affect our budget long-term,” said Ald.  Andre Chabot. “I think it’s incumbent upon us to actually do something to help  stimulate better understanding of what can help promote dental health.”

The Alex stands to gain $585,000 through an endowment fund to keep its bus  running.

CUPS is earmarked for $165,000 in capital funding for the expansion of its  dental services to include children.

CUPS now offers adult-only dental services on weekends, but wants to add  another dental chair exclusively for treating children when it moves to its new  facility at 10th Street and 10th Avenue S.W.

Building on the success of its health outreach bus, which offers medical  treatment to Calgarians living in poverty, the Alex expects its new dental bus  will cater exclusively to children, and is hoping to treat up to 12,000 a  year.

When the city stopped the flow of fluoride in Calgary’s drinking water, it  pledged to funnel $750,000 — the annual cost of adding the cavity-fighting  compound — into dental-health programs for kids in need.

The Alex Community Health  Centre’s new dental bus arrives here next week, and aims to be on streets  by September.

The $375,000 bus, paid for through donations from the Willow Park charity  classic golf tournament, arrives fully equipped with two dental chairs and X-ray  machines.

The bus is the second mobile health unit, which is paid for through  donations, said Shelley Heartwell, CEO of the Alex Community Health Centre.

It is estimated the dental bus will cost $50,000 each year to operate.

While the city’s plan to set up an endowment will help keep the bus moving,  the Alex says it will pursue provincial dollars.

Controversy over the benefits of adding fluoride to the water supply saw the  city quit using it last year. Council ruled that delivering dental services fell  outside its mandate.

Critics voiced concern that ending fluoridation limited the access of  impoverished families to the enamel-building mineral.

Low-income families identified dental heath as a top concern, according to a  United Way report.

http://www.calgaryherald.com/business/City+earmarks+from+flouridation+savings+kids+dental+care+programs/6884568/story.html#ixzz1zzDruecc