ABSTRACT
Objective. To explore the influence of high fluoride exposure on reproductive hormones in male living in endemic fluorosis villages in China.
Methods. A cross sectional study was conducted in Tongxu county in Henan Province, China. Endemic fluorosis villages and control villages were selected by random sampling according to fluoride concentration in drinking water and the prevalence of endemic fluorosis. Local male residents aged from 18 to 50 years old who were born and grew up in the investigated villages were recruited as subjects by cluster sampling. Fasting blood and urine samples were collected. The serum level of GnRH was detected using ELISA. The serum level of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), and testosterone (T) were determined by chemiluminesence immunoassay (CLIA).
Results. The serum levels of FSH were 7.82 mlU/ml, 10.20 mIU/ml and 9.57 mIU/ml in male from defluoridation villages (DFPG), high fluoride villages (HFG) and control villages (CG) respectively. FSH level in male from DFPG was significant lower than that from HFG and CG (P<0.05). The serum levels of E2 were 33.67 ng/mL, 29.17 ng/mL and 28.99 ng/mL in DPFG, HFG and CG respectively. E2 level in male from DFPG was significant higher than that from HFG and CG (P<0.05). Serum levels of E2 in CG were associated with LH (r=0.343, P=0.000), age (r=0.195, P=0.015), and inversely associated with serum FSH (r=-0.237, P=0.003), whereas this correlation was not observed for serum E2 level in DFPG and HFG.
Conclusion. Long-term fluoride exposure in drinking water may influence the reproductive hormones in males living in endemic fluorosis villages.



By: Marge Dwyer, Harvard School of Public Health News, Boston, MA July 2012 — For years health experts have been unable to agree on whether fluoride in the drinking water may be toxic to the developing human brain. Extremely high levels of fluoride are known to cause neurotoxicity in adults, and negative impacts on memory and learning have been reported in rodent studies, but little is known about the substance’s impact on children’s neurodevelopment. In a meta-analysis, researchers from Harvard School of Public Health (HSPH) and China Medical University in Shenyang for the first time combined 27 studies and found strong indications that fluoride may adversely affect cognitive development in children. Based on the findings, the authors say that this risk should not be ignored, and that more research on fluoride’s impact on the developing brain is warranted.

By: Sara Ross, Orillia Packet & Times, Orillia, Ontario 16-Jul-2012 — Orillia’s politicians have said no to fluoridating the municipal water supply.


By: Sherri Zickefoose, Calgary Herald, Calgary, Ontario 04-Jul-2012 — The city is closer to washing its hands of dental-care delivery by recommending one-time funding for charities.


